الفا فيټوپروټين

الفا فيټوپروټين (په انگرېزي: Alpha-fetoprotein AFP, α-fetoprotein; alpha-1-fetoprotein, alpha-fetoglobulin او يا هم alpha fetal protein) يو ډول پروټين دی[۱][۲] چې په انسانانو کې د AFP جين لخوا په کوډونو سمبال شوی.[۳][۴]د AFP جين د کروموزوم 4 په q مټ موقعيت لري (4q25).

الفا فيټوپروټين په پلازما کې يو عمده پروټين دی چې د جنين د ودې په بهير کې په لړمانه او نوکڅوړې کې جوړېږي. داسې گڼل کېږي چې همدا پروټين د جنيني بڼې البوميني سېروم دی. AFP د تامبې, نېکل, شحمي اسيدونو او بيليروبين سره د تړل کېدلو توان لري[۴] او د پروټينونو په مونومېريک، ډايمېرېک او ټرايمېرېک بڼو کې موندل کېږي.

جوړښت

الفا فيټوپروټين يو گلايکوپروټين دی چې د ۵۹۱ امينو اسيدونو[۵] او د کاربوهايډرېټو عاملي ډلو څخه جوړ شوی.[۶]

کړنه

الفافيټوپروټين هغه پلازما پروټين دی چې تر ټولو ډېر په انساني جنين کې موندل کېږي.

دا هم ولولئ

سرچينې

  1. Tomasi TB (1977). "Structure and function of alpha-fetoprotein". Annual review of medicine. 28: 453–65. doi:10.1146/annurev.me.28.020177.002321. PMID 67821.
  2. Mizejewski GJ (May 2001). "Alpha-fetoprotein structure and function: relevance to isoforms, epitopes, and conformational variants". Experimental Biology and Medicine. 226 (5): 377–408. PMID 11393167. Archived from the original on 2009-12-05. نه اخيستل شوی 2015-02-16. {{cite journal}}: External link in |خونديځ تړی= (help); Unknown parameter |خونديځ-تړی= ignored (help)
  3. Harper ME, Dugaiczyk A (July 1983). "Linkage of the evolutionarily-related serum albumin and alpha-fetoprotein genes within q11-22 of human chromosome 4". American Journal of Human Genetics. 35 (4): 565–72. PMC 1685723. PMID 6192711.
  4. ۴٫۰ ۴٫۱ "Entrez Gene: Alpha-fetoprotein".
  5. Pucci P, Siciliano R, Malorni A, Marino G, Tecce MF, Ceccarini C, Terrana B (May 1991). "Human alpha-fetoprotein primary structure: a mass spectrometric study". Biochemistry. 30 (20): 5061–6. doi:10.1021/bi00234a032. PMID 1709810.{{cite journal}}: سرچينه ساتل:څونوميز:ليکوالانو نوملړ (link)
  6. Seregni E, Botti C, Bombardieri E (1995). "Biochemical characteristics and clinical applications of alpha-fetoprotein isoforms". Anticancer Res. 15 (4): 1491–9. PMID 7544570.{{cite journal}}: سرچينه ساتل:څونوميز:ليکوالانو نوملړ (link)

لا نورې لوستنې

  • Nahon JL (1987). "The regulation of albumin and alpha-fetoprotein gene expression in mammals". Biochimie. 69 (5): 445–59. doi:10.1016/0300-9084(87)90082-4. PMID 2445387.
  • Tilghman SM (1989). "The structure and regulation of the alpha-fetoprotein and albumin genes". Oxf. Surv. Eukaryot. Genes. 2: 160–206. PMID 2474300.
  • Mizejewski GJ (2003). "Biological role of alpha-fetoprotein in cancer: prospects for anticancer therapy". Expert Rev Anticancer Ther. 2 (6): 709–35. doi:10.1586/14737140.2.6.709. PMID 12503217.
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  • Bansal V, Kumari K, Dixit A, Sahib MK (1991). "Interaction of human alpha fetoprotein with bilirubin". Indian J. Exp. Biol. 28 (7): 697–8. PMID 1703124.{{cite journal}}: سرچينه ساتل:څونوميز:ليکوالانو نوملړ (link)
  • Pucci P, Siciliano R, Malorni A; et al. (1991). "Human alpha-fetoprotein primary structure: a mass spectrometric study". Biochemistry. 30 (20): 5061–6. doi:10.1021/bi00234a032. PMID 1709810. {{cite journal}}: Explicit use of et al. in: |author= (help)سرچينه ساتل:څونوميز:ليکوالانو نوملړ (link)
  • Liu MC, Yu S, Sy J; et al. (1985). "Tyrosine sulfation of proteins from the human hepatoma cell line HepG2". Proceedings of the National Academy of Sciences of the United States of America. 82 (21): 7160–4. doi:10.1073/pnas.82.21.7160. PMC 390808. PMID 2414772. {{cite journal}}: Explicit use of et al. in: |author= (help)سرچينه ساتل:څونوميز:ليکوالانو نوملړ (link)
  • Gibbs PE, Zielinski R, Boyd C, Dugaiczyk A (1987). "Structure, polymorphism, and novel repeated DNA elements revealed by a complete sequence of the human alpha-fetoprotein gene". Biochemistry. 26 (5): 1332–43. doi:10.1021/bi00379a020. PMID 2436661.{{cite journal}}: سرچينه ساتل:څونوميز:ليکوالانو نوملړ (link)
  • Sakai M, Morinaga T, Urano Y; et al. (1985). "The human alpha-fetoprotein gene. Sequence organization and the 5' flanking region". J. Biol. Chem. 260 (8): 5055–60. PMID 2580830. {{cite journal}}: Explicit use of et al. in: |author= (help)سرچينه ساتل:څونوميز:ليکوالانو نوملړ (link)
  • Ruoslahti E, Pihko H, Vaheri A; et al. (1975). "Alpha fetoprotein: structure and expression in man and inbred mouse strains under normal conditions and liver injury". Johns Hopkins Med. J. Suppl. 3: 249–55. PMID 4138095. {{cite journal}}: Explicit use of et al. in: |author= (help)سرچينه ساتل:څونوميز:ليکوالانو نوملړ (link)
  • Urano Y, Sakai M, Watanabe K, Tamaoki T (1985). "Tandem arrangement of the albumin and alpha-fetoprotein genes in the human genome". Gene. 32 (3): 255–61. doi:10.1016/0378-1119(84)90001-5. PMID 6085063.{{cite journal}}: سرچينه ساتل:څونوميز:ليکوالانو نوملړ (link)
  • Beattie WG, Dugaiczyk A (1983). "Structure and evolution of human alpha-fetoprotein deduced from partial sequence of cloned cDNA". Gene. 20 (3): 415–22. doi:10.1016/0378-1119(82)90210-4. PMID 6187626.
  • Morinaga T, Sakai M, Wegmann TG, Tamaoki T (1983). "Primary structures of human alpha-fetoprotein and its mRNA". Proceedings of the National Academy of Sciences of the United States of America. 80 (15): 4604–8. doi:10.1073/pnas.80.15.4604. PMC 384092. PMID 6192439.{{cite journal}}: سرچينه ساتل:څونوميز:ليکوالانو نوملړ (link)

باندنۍ تړنې