د "پلازموډيم فالسيپارم" د بڼو تر مېنځ توپير

Resistance to antimalarial drugs, first to chloroquine and then to others was first noticed in the 1950s and has since spread all over the world. There is a real-time [[polymerase chain reaction|PCR]] test<ref>{{cite journal | author=Farcas GA, Soeller R, Zhong K, Zahirieh A, Kain KC. | title=Real-time polymerase chain reaction assay for the rapid detection and characterization of chloroquine-resistant ''Plasmodium falciparum'' malaria in returned travelers | journal=Clin Infect Dis | year=2006 | volume=42 | pages=622&ndash;7 |id=PMID 16447106}}</ref> available to look for the K76T<ref>{{cite journal | author=Djimde A, Doumbo OK, Cortese JF, ''et al.'' | title=A molecular marker for chloroquine-resistant falciparum malaria | journal=N Engl J Med | year=2001 | volume=344 | pages=257&ndash;263 | issue=4 }}</ref> mutation in PfCRT which results in chloroquine resistance in ''P. falciparum'', but this is not yet commercially available.
 
==Vaccinationواکسين==
Although an antimalarial vaccine is urgently needed, infected individuals never develop a sterilizing (complete) immunity, making the prospects for such a vaccine dim. The parasites live inside cells, where they are largely hidden from the immune response. Infection has a profound effect on the [[immune system]] including immune suppression. [[Dendritic cell]]s suffer a maturation defect following interaction with infected [[erythrocytes]] and become unable to induce protective liver-stage [[immunity (medical)|immunity]]. Infected erythrocytes directly adhere to and activate peripheral blood [[B cells]] from nonimmune donors. The ''var'' gene products, a group of highly expressed surface [[antigen]]s, bind the Fab and Fc fragments of human [[immunoglobulin]]s in a fashion similar to protein A to ''[[Staphylococcus aureus]]'' and this may offer some protection to the parasite from the human immune system. Despite the poor prospects for a fully protective vaccine, it may be possible to develop a vaccine that would reduce the severity of malaria for children living in endemic areas.
 
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